Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/UPF0150(antitoxin) |
Location | 1077364..1078000 | Replicon | chromosome |
Accession | NZ_CP113163 | ||
Organism | Citrobacter braakii strain LBA3 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | - |
Locus tag | MKJ05_RS05170 | Protein ID | WP_200109114.1 |
Coordinates | 1077364..1077552 (+) | Length | 63 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | - |
Locus tag | MKJ05_RS05175 | Protein ID | WP_199142843.1 |
Coordinates | 1077584..1078000 (+) | Length | 139 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MKJ05_RS05150 (MKJ05_05150) | 1074144..1074374 | - | 231 | WP_114682896.1 | DUF2554 family protein | - |
MKJ05_RS05155 (MKJ05_05155) | 1074564..1074689 | - | 126 | WP_267588790.1 | DUF2474 domain-containing protein | - |
MKJ05_RS05160 (MKJ05_05160) | 1074689..1075699 | - | 1011 | WP_267588791.1 | cytochrome d ubiquinol oxidase subunit II | - |
MKJ05_RS05165 (MKJ05_05165) | 1075699..1077102 | - | 1404 | WP_267588792.1 | cytochrome ubiquinol oxidase subunit I | - |
MKJ05_RS05170 (MKJ05_05170) | 1077364..1077552 | + | 189 | WP_200109114.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
MKJ05_RS05175 (MKJ05_05175) | 1077584..1078000 | + | 417 | WP_199142843.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
MKJ05_RS05180 (MKJ05_05180) | 1078093..1079502 | + | 1410 | WP_199142780.1 | PLP-dependent aminotransferase family protein | - |
MKJ05_RS05185 (MKJ05_05185) | 1079832..1080977 | + | 1146 | WP_047417375.1 | ABC transporter substrate-binding protein | - |
MKJ05_RS05190 (MKJ05_05190) | 1080994..1082010 | + | 1017 | WP_267588793.1 | ABC transporter ATP-binding protein | - |
MKJ05_RS05195 (MKJ05_05195) | 1082011..1082955 | + | 945 | WP_199142776.1 | ABC transporter permease | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7139.22 Da Isoelectric Point: 11.5775
>T265432 WP_200109114.1 NZ_CP113163:1077364-1077552 [Citrobacter braakii]
VKQSEFRRWLESQGVVVTNGSNHLKLRYHGRRSVMPRHPGDEIKEALRKSILKQLGLQSSSI
VKQSEFRRWLESQGVVVTNGSNHLKLRYHGRRSVMPRHPGDEIKEALRKSILKQLGLQSSSI
Download Length: 189 bp
Antitoxin
Download Length: 139 a.a. Molecular weight: 15019.34 Da Isoelectric Point: 4.7119
>AT265432 WP_199142843.1 NZ_CP113163:1077584-1078000 [Citrobacter braakii]
MRYPVNLIPAVEGGFVVSFPDIPEALTQGETRHGALLAAQSALVTAFEFYFDDNEPIPLPSAVGAEGDYVEIPLSIASKV
LLLNAFLESKITQQELANRIGRPKQEITRLFDLKHATKIDAVQIAARALGKELSVTML
MRYPVNLIPAVEGGFVVSFPDIPEALTQGETRHGALLAAQSALVTAFEFYFDDNEPIPLPSAVGAEGDYVEIPLSIASKV
LLLNAFLESKITQQELANRIGRPKQEITRLFDLKHATKIDAVQIAARALGKELSVTML
Download Length: 417 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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