Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1077364..1078000 Replicon chromosome
Accession NZ_CP113163
Organism Citrobacter braakii strain LBA3

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag MKJ05_RS05170 Protein ID WP_200109114.1
Coordinates 1077364..1077552 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag MKJ05_RS05175 Protein ID WP_199142843.1
Coordinates 1077584..1078000 (+) Length 139 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKJ05_RS05150 (MKJ05_05150) 1074144..1074374 - 231 WP_114682896.1 DUF2554 family protein -
MKJ05_RS05155 (MKJ05_05155) 1074564..1074689 - 126 WP_267588790.1 DUF2474 domain-containing protein -
MKJ05_RS05160 (MKJ05_05160) 1074689..1075699 - 1011 WP_267588791.1 cytochrome d ubiquinol oxidase subunit II -
MKJ05_RS05165 (MKJ05_05165) 1075699..1077102 - 1404 WP_267588792.1 cytochrome ubiquinol oxidase subunit I -
MKJ05_RS05170 (MKJ05_05170) 1077364..1077552 + 189 WP_200109114.1 type II toxin-antitoxin system HicA family toxin Toxin
MKJ05_RS05175 (MKJ05_05175) 1077584..1078000 + 417 WP_199142843.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
MKJ05_RS05180 (MKJ05_05180) 1078093..1079502 + 1410 WP_199142780.1 PLP-dependent aminotransferase family protein -
MKJ05_RS05185 (MKJ05_05185) 1079832..1080977 + 1146 WP_047417375.1 ABC transporter substrate-binding protein -
MKJ05_RS05190 (MKJ05_05190) 1080994..1082010 + 1017 WP_267588793.1 ABC transporter ATP-binding protein -
MKJ05_RS05195 (MKJ05_05195) 1082011..1082955 + 945 WP_199142776.1 ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-57)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 63 a.a.        Molecular weight: 7139.22 Da        Isoelectric Point: 11.5775

>T265432 WP_200109114.1 NZ_CP113163:1077364-1077552 [Citrobacter braakii]
VKQSEFRRWLESQGVVVTNGSNHLKLRYHGRRSVMPRHPGDEIKEALRKSILKQLGLQSSSI

Download         Length: 189 bp


Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15019.34 Da        Isoelectric Point: 4.7119

>AT265432 WP_199142843.1 NZ_CP113163:1077584-1078000 [Citrobacter braakii]
MRYPVNLIPAVEGGFVVSFPDIPEALTQGETRHGALLAAQSALVTAFEFYFDDNEPIPLPSAVGAEGDYVEIPLSIASKV
LLLNAFLESKITQQELANRIGRPKQEITRLFDLKHATKIDAVQIAARALGKELSVTML

Download         Length: 417 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References