Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 1009424..1010090 Replicon chromosome
Accession NZ_CP113116
Organism Mycobacterium sp. Aquia_213

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag LMQ14_RS04950 Protein ID WP_267733703.1
Coordinates 1009617..1010090 (+) Length 158 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID -
Locus tag LMQ14_RS04945 Protein ID WP_085221917.1
Coordinates 1009424..1009612 (+) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMQ14_RS04930 (LMQ14_04930) 1004760..1005299 - 540 WP_267733700.1 G/U mismatch-specific DNA glycosylase -
LMQ14_RS04935 (LMQ14_04935) 1005344..1006924 + 1581 WP_267733701.1 serine hydrolase -
LMQ14_RS04940 (LMQ14_04940) 1006921..1009320 + 2400 WP_267733702.1 cation-translocating P-type ATPase -
LMQ14_RS04945 (LMQ14_04945) 1009424..1009612 + 189 WP_085221917.1 antitoxin Antitoxin
LMQ14_RS04950 (LMQ14_04950) 1009617..1010090 + 474 WP_267733703.1 SRPBCC family protein Toxin
LMQ14_RS04955 (LMQ14_04955) 1010074..1011315 + 1242 WP_267733704.1 cyclopropane-fatty-acyl-phospholipid synthase family protein -
LMQ14_RS04960 (LMQ14_04960) 1011387..1012160 + 774 WP_267733705.1 VOC family protein -
LMQ14_RS04965 (LMQ14_04965) 1012236..1012670 + 435 WP_267733706.1 hypothetical protein -
LMQ14_RS04970 (LMQ14_04970) 1012674..1013159 - 486 WP_267733707.1 VOC family protein -
LMQ14_RS04975 (LMQ14_04975) 1013197..1014711 - 1515 WP_267733708.1 carotenoid oxygenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-52)


Sequences

Toxin        


Download         Length: 158 a.a.        Molecular weight: 17103.80 Da        Isoelectric Point: 10.3744

>T265429 WP_267733703.1 NZ_CP113116:1009617-1010090 [Mycobacterium sp. Aquia_213]
MAKLSGSIDVPLSPERAWTHASDLSRFKDWLSIHRVWRSKLPDDLQKGTVIESIVEVKGMLNRIKWTIVHYKPPEAMTLN
GDGVGGVKVKLIAKVKPKDDGSVVSFDVHLGGPALFGPIGMIVAAALRSDINESLERFVTVFTAPDPGRNGHGGARR

Download         Length: 474 bp

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 6764.45 Da        Isoelectric Point: 4.5086

>AT265429 WP_085221917.1 NZ_CP113116:1009424-1009612 [Mycobacterium sp. Aquia_213]
MGFLDKAKDLLAQNADKVETAIDKAGEFVDDKTQGKYSDTIHKVQEEAKKAIDAQGPGDQQN

Download         Length: 189 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References