Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1661635..1662133 Replicon chromosome
Accession NZ_CP113115
Organism Streptococcus pneumoniae strain NP2

Toxin (Protein)


Gene name relE Uniprot ID B1IC19
Locus tag OTU47_RS08765 Protein ID WP_001809704.1
Coordinates 1661635..1661889 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag OTU47_RS08770 Protein ID WP_000208080.1
Coordinates 1661891..1662133 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OTU47_RS08750 (OTU47_08750) 1656908..1659376 - 2469 WP_001152993.1 DNA gyrase subunit A -
OTU47_RS08755 (OTU47_08755) 1659570..1660556 + 987 WP_000204727.1 L-lactate dehydrogenase -
OTU47_RS08760 (OTU47_08760) 1660845..1661588 - 744 WP_001037000.1 potassium channel family protein -
OTU47_RS08765 (OTU47_08765) 1661635..1661889 - 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OTU47_RS08770 (OTU47_08770) 1661891..1662133 - 243 WP_000208080.1 DUF6290 family protein Antitoxin
OTU47_RS08775 (OTU47_08775) 1662224..1663033 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
OTU47_RS08780 (OTU47_08780) 1663035..1664384 - 1350 WP_000886213.1 cell wall metabolism sensor histidine kinase VicK -
OTU47_RS08785 (OTU47_08785) 1664377..1665081 - 705 WP_000722076.1 response regulator YycF -
OTU47_RS08790 (OTU47_08790) 1665137..1666312 - 1176 WP_000886152.1 A/G-specific adenine glycosylase -
OTU47_RS08795 (OTU47_08795) 1666409..1666534 + 126 WP_001818232.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10098.79 Da        Isoelectric Point: 10.7632

>T265428 WP_001809704.1 NZ_CP113115:c1661889-1661635 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT265428 WP_000208080.1 NZ_CP113115:c1662133-1661891 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853PEW4

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References