Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 964287..964955 Replicon chromosome
Accession NZ_CP113115
Organism Streptococcus pneumoniae strain NP2

Toxin (Protein)


Gene name hicA Uniprot ID C1C927
Locus tag OTU47_RS05235 Protein ID WP_001132282.1
Coordinates 964287..964466 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag OTU47_RS05240 Protein ID WP_000961810.1
Coordinates 964503..964955 (+) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OTU47_RS05205 (OTU47_05205) 959305..960150 + 846 WP_000819520.1 carbohydrate ABC transporter permease -
OTU47_RS05210 (OTU47_05210) 960160..961479 + 1320 WP_000608880.1 glycoside hydrolase family 32 protein -
OTU47_RS05220 (OTU47_05220) 962026..963297 - 1272 WP_001113215.1 replication-associated recombination protein A -
OTU47_RS05225 (OTU47_05225) 963567..963806 + 240 WP_000818078.1 hypothetical protein -
OTU47_RS05230 (OTU47_05230) 963971..964150 + 180 WP_001048906.1 hypothetical protein -
OTU47_RS05235 (OTU47_05235) 964287..964466 + 180 WP_001132282.1 type II toxin-antitoxin system HicA family toxin Toxin
OTU47_RS05240 (OTU47_05240) 964503..964955 + 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OTU47_RS05245 (OTU47_05245) 965246..965716 + 471 WP_000257094.1 DUF3013 family protein -
OTU47_RS05250 (OTU47_05250) 965735..966823 + 1089 WP_000719700.1 site-2 protease family protein -
OTU47_RS05255 (OTU47_05255) 966804..967232 + 429 WP_000418161.1 NUDIX hydrolase -
OTU47_RS05260 (OTU47_05260) 967367..968320 + 954 WP_000970769.1 50S ribosomal protein L11 methyltransferase -
OTU47_RS05265 (OTU47_05265) 968322..969065 + 744 WP_001188201.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.95 Da        Isoelectric Point: 11.0174

>T265427 WP_001132282.1 NZ_CP113115:964287-964466 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERLITIPHGELNKYTERGIRKQAGL

Download         Length: 180 bp

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT265427 WP_000961810.1 NZ_CP113115:964503-964955 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E7SUI3

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References