265426

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1840626..1841294 Replicon chromosome
Accession NZ_CP113114
Organism Streptococcus pneumoniae strain NP1

Toxin (Protein)


Gene name hicA Uniprot ID C1C927
Locus tag OTU45_RS09330 Protein ID WP_001132282.1
Coordinates 1841115..1841294 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag OTU45_RS09325 Protein ID WP_000961810.1
Coordinates 1840626..1841078 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OTU45_RS09300 (OTU45_09300) 1836516..1837259 - 744 WP_001188201.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
OTU45_RS09305 (OTU45_09305) 1837261..1838214 - 954 WP_000970769.1 50S ribosomal protein L11 methyltransferase -
OTU45_RS09310 (OTU45_09310) 1838349..1838777 - 429 WP_000418161.1 NUDIX hydrolase -
OTU45_RS09315 (OTU45_09315) 1838758..1839846 - 1089 WP_000719700.1 site-2 protease family protein -
OTU45_RS09320 (OTU45_09320) 1839865..1840335 - 471 WP_000257094.1 DUF3013 family protein -
OTU45_RS09325 (OTU45_09325) 1840626..1841078 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OTU45_RS09330 (OTU45_09330) 1841115..1841294 - 180 WP_001132282.1 type II toxin-antitoxin system HicA family toxin Toxin
OTU45_RS09335 (OTU45_09335) 1841431..1841610 - 180 WP_001048906.1 hypothetical protein -
OTU45_RS09340 (OTU45_09340) 1841775..1842014 - 240 WP_000818078.1 hypothetical protein -
OTU45_RS09345 (OTU45_09345) 1842284..1843555 + 1272 WP_001113215.1 replication-associated recombination protein A -
OTU45_RS09355 (OTU45_09355) 1844102..1845421 - 1320 WP_000608880.1 glycoside hydrolase family 32 protein -
OTU45_RS09360 (OTU45_09360) 1845431..1846276 - 846 WP_000819520.1 carbohydrate ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.95 Da        Isoelectric Point: 11.0174

>T265426 WP_001132282.1 NZ_CP113114:c1841294-1841115 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERLITIPHGELNKYTERGIRKQAGL

Download         Length: 180 bp

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT265426 WP_000961810.1 NZ_CP113114:c1841078-1840626 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E7SUI3

Antitoxin

Source ID Structure
AlphaFold DB G0IC64

References