265425

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1247383..1247881 Replicon chromosome
Accession NZ_CP113114
Organism Streptococcus pneumoniae strain NP1

Toxin (Protein)


Gene name relE Uniprot ID B1IC19
Locus tag OTU45_RS06195 Protein ID WP_001809704.1
Coordinates 1247383..1247637 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag OTU45_RS06200 Protein ID WP_000208080.1
Coordinates 1247639..1247881 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OTU45_RS06180 (OTU45_06180) 1242656..1245124 - 2469 WP_001152993.1 DNA gyrase subunit A -
OTU45_RS06185 (OTU45_06185) 1245318..1246304 + 987 WP_000204727.1 L-lactate dehydrogenase -
OTU45_RS06190 (OTU45_06190) 1246593..1247336 - 744 WP_001037000.1 potassium channel family protein -
OTU45_RS06195 (OTU45_06195) 1247383..1247637 - 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OTU45_RS06200 (OTU45_06200) 1247639..1247881 - 243 WP_000208080.1 DUF6290 family protein Antitoxin
OTU45_RS06205 (OTU45_06205) 1247972..1248781 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
OTU45_RS06210 (OTU45_06210) 1248783..1250132 - 1350 WP_000886213.1 cell wall metabolism sensor histidine kinase VicK -
OTU45_RS06215 (OTU45_06215) 1250125..1250829 - 705 WP_000722076.1 response regulator YycF -
OTU45_RS06220 (OTU45_06220) 1250885..1252060 - 1176 WP_000886152.1 A/G-specific adenine glycosylase -
OTU45_RS06225 (OTU45_06225) 1252157..1252282 + 126 WP_001818232.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10098.79 Da        Isoelectric Point: 10.7632

>T265425 WP_001809704.1 NZ_CP113114:c1247637-1247383 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT265425 WP_000208080.1 NZ_CP113114:c1247881-1247639 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853PEW4

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References