Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 5632594..5633099 Replicon chromosome
Accession NZ_CP113106
Organism Pseudomonas aeruginosa strain BIAI 157

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag OSZ59_RS26525 Protein ID WP_003083773.1
Coordinates 5632818..5633099 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag OSZ59_RS26520 Protein ID WP_003083775.1
Coordinates 5632594..5632821 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSZ59_RS26495 (OSZ59_26495) 5627612..5629105 + 1494 WP_016263977.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
OSZ59_RS26500 (OSZ59_26500) 5629274..5630701 + 1428 WP_267749919.1 GABA permease -
OSZ59_RS26505 (OSZ59_26505) 5630783..5631124 - 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
OSZ59_RS26510 (OSZ59_26510) 5631197..5631697 - 501 WP_003112629.1 LEA type 2 family protein -
OSZ59_RS26515 (OSZ59_26515) 5631798..5632418 + 621 WP_003101226.1 hypothetical protein -
OSZ59_RS26520 (OSZ59_26520) 5632594..5632821 + 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
OSZ59_RS26525 (OSZ59_26525) 5632818..5633099 + 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
OSZ59_RS26530 (OSZ59_26530) 5633399..5634308 + 910 Protein_5242 LysR family transcriptional regulator -
OSZ59_RS26535 (OSZ59_26535) 5634340..5634750 - 411 WP_003101225.1 aegerolysin family protein -
OSZ59_RS26540 (OSZ59_26540) 5634930..5635664 - 735 WP_003117208.1 GntR family transcriptional regulator -
OSZ59_RS26545 (OSZ59_26545) 5635765..5636451 - 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
OSZ59_RS26550 (OSZ59_26550) 5636500..5637849 - 1350 WP_079279937.1 C4-dicarboxylate transporter DctA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T265424 WP_003083773.1 NZ_CP113106:5632818-5633099 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT265424 WP_003083775.1 NZ_CP113106:5632594-5632821 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References