Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 3596673..3597930 Replicon chromosome
Accession NZ_CP113106
Organism Pseudomonas aeruginosa strain BIAI 157

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag OSZ59_RS16675 Protein ID WP_023084953.1
Coordinates 3596673..3597428 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag OSZ59_RS16680 Protein ID WP_003086329.1
Coordinates 3597562..3597930 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSZ59_RS16665 (OSZ59_16665) 3591846..3594389 + 2544 WP_003112526.1 acyl-homoserine-lactone acylase QuiP -
OSZ59_RS16670 (OSZ59_16670) 3594544..3595905 - 1362 WP_003081943.1 DNA recombination protein RmuC -
OSZ59_RS16675 (OSZ59_16675) 3596673..3597428 - 756 WP_023084953.1 RES family NAD+ phosphorylase Toxin
OSZ59_RS16680 (OSZ59_16680) 3597562..3597930 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
OSZ59_RS16685 (OSZ59_16685) 3598003..3599289 - 1287 WP_023096923.1 FAD-binding oxidoreductase -
OSZ59_RS16690 (OSZ59_16690) 3599345..3600934 - 1590 WP_079384792.1 aldehyde dehydrogenase family protein -
OSZ59_RS16695 (OSZ59_16695) 3601012..3601488 + 477 WP_031675481.1 elongation factor GreAB -
OSZ59_RS16700 (OSZ59_16700) 3601491..3601766 - 276 WP_169057979.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28310.49 Da        Isoelectric Point: 7.7294

>T265423 WP_023084953.1 NZ_CP113106:c3597428-3596673 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGMRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT265423 WP_003086329.1 NZ_CP113106:c3597930-3597562 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References