Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2565743..2566257 Replicon chromosome
Accession NZ_CP113105
Organism Staphylococcus aureus strain BIAI 117

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag OSZ56_RS12495 Protein ID WP_000581791.1
Coordinates 2566048..2566257 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag OSZ56_RS12490 Protein ID WP_000138934.1
Coordinates 2565743..2566036 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSZ56_RS12470 (2561206) 2561206..2561847 + 642 WP_000483150.1 thiamine phosphate synthase -
OSZ56_RS12475 (2561933) 2561933..2562805 + 873 WP_000725802.1 membrane protein insertase YidC -
OSZ56_RS12480 (2563418) 2563418..2564065 - 648 WP_001187612.1 HD domain-containing protein -
OSZ56_RS12485 (2564093) 2564093..2565577 - 1485 WP_000571560.1 cardiolipin synthase -
OSZ56_RS12490 (2565743) 2565743..2566036 + 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
OSZ56_RS12495 (2566048) 2566048..2566257 + 210 WP_000581791.1 heavy metal-associated domain-containing protein Toxin
OSZ56_RS12500 (2566385) 2566385..2566522 + 138 WP_000828354.1 Lmo0850 family protein -
OSZ56_RS12505 (2566934) 2566934..2567617 + 684 Protein_2424 transposase -
OSZ56_RS12510 (2567778) 2567778..2568980 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
OSZ56_RS12515 (2569298) 2569298..2570368 + 1071 WP_000159638.1 D-alanine--D-alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2567441..2567617 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T265413 WP_000581791.1 NZ_CP113105:2566048-2566257 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT265413 WP_000138934.1 NZ_CP113105:2565743-2566036 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References