Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 14652..15428 Replicon chromosome
Accession NZ_CP113105
Organism Staphylococcus aureus strain BIAI 117

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag OSZ56_RS00190 Protein ID WP_000031108.1
Coordinates 15276..15428 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag OSZ56_RS00185 Protein ID WP_001251219.1
Coordinates 14652..15251 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSZ56_RS00165 (10564) 10564..12021 + 1458 WP_000649898.1 ABC transporter permease subunit -
OSZ56_RS00170 (12014) 12014..12736 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
OSZ56_RS00175 (12887) 12887..14018 + 1132 Protein_4 tRNA epoxyqueuosine(34) reductase QueG -
OSZ56_RS00180 (14023) 14023..14493 + 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
OSZ56_RS00185 (14652) 14652..15251 + 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
OSZ56_RS00190 (15276) 15276..15428 + 153 WP_000031108.1 SAS053 family protein Toxin
OSZ56_RS00195 (16029) 16029..16424 + 396 WP_000901019.1 hypothetical protein -
OSZ56_RS00200 (16620) 16620..18005 + 1386 WP_000116227.1 class II fumarate hydratase -
OSZ56_RS00205 (18461) 18461..19282 - 822 WP_000669380.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T265405 WP_000031108.1 NZ_CP113105:15276-15428 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT265405 WP_001251219.1 NZ_CP113105:14652-15251 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References