Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5549065..5549762 Replicon chromosome
Accession NZ_CP113097
Organism Pseudomonas putida strain WYTS.T61

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag OSW16_RS25590 Protein ID WP_267819423.1
Coordinates 5549583..5549762 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag OSW16_RS25585 Protein ID WP_267819421.1
Coordinates 5549065..5549472 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSW16_RS25565 (OSW16_25565) 5544248..5545120 + 873 WP_267819413.1 hypothetical protein -
OSW16_RS25570 (OSW16_25570) 5545117..5545890 + 774 WP_267819415.1 FAD-dependent thymidylate synthase -
OSW16_RS25575 (OSW16_25575) 5545955..5547535 - 1581 WP_267819417.1 TIGR04141 family sporadically distributed protein -
OSW16_RS25580 (OSW16_25580) 5548073..5548720 + 648 WP_267819419.1 hypothetical protein -
OSW16_RS25585 (OSW16_25585) 5549065..5549472 - 408 WP_267819421.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OSW16_RS25590 (OSW16_25590) 5549583..5549762 - 180 WP_267819423.1 type II toxin-antitoxin system HicA family toxin Toxin
OSW16_RS25595 (OSW16_25595) 5550283..5551572 - 1290 WP_267819426.1 OprD family porin -
OSW16_RS25600 (OSW16_25600) 5552047..5552244 - 198 WP_241805553.1 hypothetical protein -
OSW16_RS25605 (OSW16_25605) 5552425..5553531 - 1107 WP_267819429.1 agmatine deiminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6695.87 Da        Isoelectric Point: 10.9062

>T265403 WP_267819423.1 NZ_CP113097:c5549762-5549583 [Pseudomonas putida]
VNSRELIARIEADGWVEVRVKGSHHHFKHPTKPGLVTIPHPKKDLLLKTINSILKQAQL

Download         Length: 180 bp

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14580.53 Da        Isoelectric Point: 4.5209

>AT265403 WP_267819421.1 NZ_CP113097:c5549472-5549065 [Pseudomonas putida]
VLYPIAILPGDEQHAWGVEVPDIPGCFSAGDDLDDALAMAKEAIEGHLELLAEDGAVIPTANKLTVHSANPEYAGCTWAV
VDIDITKYLGKAEKLNITLPGHLLNRIDEYVKHHPEQKSRSGFLASAALRVLQES

Download         Length: 408 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References