Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 4409365..4411046 Replicon chromosome
Accession NZ_CP113097
Organism Pseudomonas putida strain WYTS.T61

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag OSW16_RS20255 Protein ID WP_267817982.1
Coordinates 4409365..4410222 (+) Length 286 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag OSW16_RS20260 Protein ID WP_241806133.1
Coordinates 4410228..4411046 (+) Length 273 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSW16_RS20230 (OSW16_20230) 4405366..4406202 + 837 WP_267824058.1 ABC transporter ATP-binding protein -
OSW16_RS20235 (OSW16_20235) 4406258..4407235 + 978 WP_241806134.1 ABC transporter substrate-binding protein -
OSW16_RS20240 (OSW16_20240) 4407265..4408041 + 777 WP_241806050.1 ABC transporter permease -
OSW16_RS20245 (OSW16_20245) 4408038..4408805 + 768 WP_267817980.1 SDR family oxidoreductase -
OSW16_RS20250 (OSW16_20250) 4408821..4409360 + 540 WP_241806048.1 cupin domain-containing protein -
OSW16_RS20255 (OSW16_20255) 4409365..4410222 + 858 WP_267817982.1 alpha/beta fold hydrolase Toxin
OSW16_RS20260 (OSW16_20260) 4410228..4411046 + 819 WP_241806133.1 IclR family transcriptional regulator Antitoxin
OSW16_RS20265 (OSW16_20265) 4411048..4411845 + 798 WP_267817984.1 SDR family oxidoreductase -
OSW16_RS20270 (OSW16_20270) 4411838..4413520 + 1683 WP_241806045.1 thiamine pyrophosphate-binding protein -
OSW16_RS20275 (OSW16_20275) 4413531..4414334 + 804 WP_241806044.1 aspartate dehydrogenase -
OSW16_RS20280 (OSW16_20280) 4414345..4415835 + 1491 WP_267817987.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(40-138)

Antitoxin

Transcription regulator IclR, C-terminal

(131-253)


Sequences

Toxin        


Download         Length: 286 a.a.        Molecular weight: 29838.51 Da        Isoelectric Point: 8.2716

>T265401 WP_267817982.1 NZ_CP113097:4409365-4410222 [Pseudomonas putida]
MMPITLIAPLLSLLEQRFAERLLRLGQGLQAVREAGSGAAIVLLHGIGSGAASWLQVALNLSERARVIAWDAPGYGQSTP
LPKAVPGASDYAGRLLQTLDALGIERCVLVGHSLGALTAAAFAQAHPQRVKRLVLLSPARGYGAQPAQGLAVRSKRLHSL
AHLGIGQMARERSAHLLSPDAGAQALAWVQWNMARLQPHGYRQAIELLCGDQLLRHAPLAVPCEVHCGSADSITRADDCQ
ALADALGAPFYLIPGAGHACAIEQPDTVTGLLARALDASLTGSAL

Download         Length: 858 bp

Antitoxin


Download         Length: 273 a.a.        Molecular weight: 30113.56 Da        Isoelectric Point: 6.6429

>AT265401 WP_241806133.1 NZ_CP113097:4410228-4411046 [Pseudomonas putida]
MDPSKENQDKYIVPGLERGLLLLCEFSRQNRTLTAPELARRLSLPRSTIFRLLTTLETMGFVTRSGNEYRLGMSVLRLGF
EYLASLELTELGQPLLARLCDRLNYPSNLVVRDGRSIVYVAKVSPPSVFSSAVTVGTRLPAHATVLGRILLADLSLSELR
ELYPEEHLEQFSPCTPKTVLELFDLVQADRLRGYVSGEGFFESTISTVAAPVRDDSGQVVAALGLTIPTVQIGHVNFDNL
LGQVRGSADELSRLLNYTPNTGHHRVTALMRD

Download         Length: 819 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References