Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 47217..47743 Replicon plasmid unnamed2
Accession NZ_CP113087
Organism Pantoea agglomerans strain AB378

Toxin (Protein)


Gene name relE Uniprot ID A0A7X2SUG9
Locus tag OSE17_RS21620 Protein ID WP_033759930.1
Coordinates 47217..47504 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A8X8DPB7
Locus tag OSE17_RS21625 Protein ID WP_010257033.1
Coordinates 47504..47743 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSE17_RS21595 (OSE17_21595) 43119..44144 - 1026 WP_010671942.1 alpha/beta hydrolase -
OSE17_RS21600 (OSE17_21600) 44213..45337 - 1125 WP_228312816.1 MFS transporter -
OSE17_RS21605 (OSE17_21605) 45540..46436 + 897 WP_010257019.1 LysR family transcriptional regulator -
OSE17_RS21610 (OSE17_21610) 46500..46676 - 177 WP_010257023.1 KGG domain-containing protein -
OSE17_RS21615 (OSE17_21615) 46876..47172 + 297 WP_039387382.1 hypothetical protein -
OSE17_RS21620 (OSE17_21620) 47217..47504 - 288 WP_033759930.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OSE17_RS21625 (OSE17_21625) 47504..47743 - 240 WP_010257033.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OSE17_RS21630 (OSE17_21630) 48103..50076 + 1974 WP_191914328.1 methyl-accepting chemotaxis protein -
OSE17_RS21635 (OSE17_21635) 50181..51197 + 1017 WP_010257039.1 NAD(P)-dependent alcohol dehydrogenase -
OSE17_RS21640 (OSE17_21640) 51247..51915 - 669 WP_267713334.1 DUF2268 domain-containing putative Zn-dependent protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..183838 183838


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-77)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11076.95 Da        Isoelectric Point: 10.3173

>T265383 WP_033759930.1 NZ_CP113087:c47504-47217 [Pantoea agglomerans]
MTWQLEFDQRALKEWRKLGPTVREQLKKKLAECLESPRIEANKLSGMPDCYKIKLKSSGYRLVYQVIDDRVVVFVVAVGK
RERSEVYSAASRRLS

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9002.33 Da        Isoelectric Point: 4.3410

>AT265383 WP_010257033.1 NZ_CP113087:c47743-47504 [Pantoea agglomerans]
MGTINIRIDDDLKTRSYAALEKMGVTPSDALRLMLEYIADNERLPFKQTLLSDEDAALVDIVKERLRNPEPVRVTLDDL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7X2SUG9

Antitoxin

Source ID Structure

References