Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 305923..306833 Replicon plasmid unnamed1
Accession NZ_CP113086
Organism Pantoea agglomerans strain AB378

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag OSE17_RS20245 Protein ID WP_045139959.1
Coordinates 306363..306833 (+) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A7X5S5X4
Locus tag OSE17_RS20240 Protein ID WP_033760867.1
Coordinates 305923..306366 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSE17_RS20215 (OSE17_20215) 302144..303043 - 900 WP_267713287.1 alpha/beta hydrolase -
OSE17_RS20220 (OSE17_20220) 303094..303708 - 615 WP_267713288.1 TetR/AcrR family transcriptional regulator -
OSE17_RS20225 (OSE17_20225) 303922..304339 + 418 Protein_288 LysR substrate-binding domain-containing protein -
OSE17_RS20230 (OSE17_20230) 304374..305363 - 990 WP_172608587.1 aldo/keto reductase -
OSE17_RS20235 (OSE17_20235) 305389..305541 - 153 Protein_290 aldo/keto reductase -
OSE17_RS20240 (OSE17_20240) 305923..306366 + 444 WP_033760867.1 DUF2384 domain-containing protein Antitoxin
OSE17_RS20245 (OSE17_20245) 306363..306833 + 471 WP_045139959.1 RES family NAD+ phosphorylase Toxin
OSE17_RS20250 (OSE17_20250) 307005..308036 + 1032 WP_033760863.1 AI-2E family transporter -
OSE17_RS20255 (OSE17_20255) 308025..310754 - 2730 WP_267713289.1 cation-transporting P-type ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - iroN 1..555125 555125


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre

(16-147)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17508.98 Da        Isoelectric Point: 4.7790

>T265382 WP_045139959.1 NZ_CP113086:306363-306833 [Pantoea agglomerans]
MILYRLTKTKYLSTAWTGFGAKEAGGRWNSIGISMVYVSETASLTLLETLVHLHSAHILDAFTLLRIDVPDVLIQTADIT
ELPANWADEDAPAELADYGDAWCSACDAVALRVPSALSPVEYNYLLNPEHPEFFRIVQQAEAIPFRFDRRLKPDRK

Download         Length: 471 bp

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16489.88 Da        Isoelectric Point: 9.9250

>AT265382 WP_033760867.1 NZ_CP113086:305923-306366 [Pantoea agglomerans]
MKTFSFSANKTRPPRLWQAAGLNNADGVALLGQINEGLDGNVAHLIVNWAKITQNDLRKMSGIPSTTFSRSVKAKFSAEQ
SERLVRIIRVIDRAVELFEGDKDEAQKWLNEPNRALSWKMPAELMASETGAYEVMKLITRLEHGVYS

Download         Length: 444 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7X5S5X4

References