Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2878122..2879683 Replicon chromosome
Accession NZ_CP113085
Organism Pantoea agglomerans strain AB378

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OSE17_RS13110 Protein ID WP_191913882.1
Coordinates 2878370..2879683 (+) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OSE17_RS13105 Protein ID WP_010670157.1
Coordinates 2878122..2878370 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSE17_RS13085 (OSE17_13085) 2873369..2875594 + 2226 WP_191913883.1 iron ABC transporter permease -
OSE17_RS13090 (OSE17_13090) 2875591..2876652 + 1062 WP_061901438.1 ABC transporter ATP-binding protein -
OSE17_RS13095 (OSE17_13095) 2876676..2877470 + 795 WP_033757665.1 inositol monophosphatase family protein -
OSE17_RS13100 (OSE17_13100) 2877504..2877941 - 438 WP_111533813.1 GNAT family N-acetyltransferase -
OSE17_RS13105 (OSE17_13105) 2878122..2878370 + 249 WP_010670157.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
OSE17_RS13110 (OSE17_13110) 2878370..2879683 + 1314 WP_191913882.1 type II toxin-antitoxin system HipA family toxin Toxin
OSE17_RS13115 (OSE17_13115) 2879788..2879994 + 207 WP_191913881.1 type II toxin-antitoxin system MqsA family antitoxin -
OSE17_RS13120 (OSE17_13120) 2880166..2881587 + 1422 WP_191913880.1 M24 family metallopeptidase -
OSE17_RS13125 (OSE17_13125) 2881663..2883708 + 2046 WP_191913879.1 FUSC family protein -
OSE17_RS13130 (OSE17_13130) 2884094..2884429 - 336 WP_022625647.1 gamma-glutamylcyclotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(9-54)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 49219.80 Da        Isoelectric Point: 8.4299

>T265379 WP_191913882.1 NZ_CP113085:2878370-2879683 [Pantoea agglomerans]
MQRLIAWMNGERVGVLTRQRNGAHEFQYDTGWLSNPLSRPLSLSMPLQVRAITSHAVINFFDNLLPDSPLIRDRIVARYQ
IKSRQPFDLLQEVGRDSVGATMLLPPDMPLPVLQARYEVLDETRLESVLSAYQSDIPLGMLREETDFRISVAGAQEKTAL
LLTDEGWSIPAGATPTSHIIKLPIGEIKQPAATLDMRESVENEYLCLALARALGIDVPQATIIRAGQMRALAVERFDRRW
SRDKTRLIRLPQEDFCQALGLPSSTKYESDGGPGIAEIMQILMGSSNSIEDRYRFMMFQVFQWLIGATDGHAKNFSLFIE
RGGSYRLTPFYDVISAYPVLGGTGLNKRALKLAMGLRATKGKKTEIDKIFPRHFIATAKSVSFDRDSLQQIFDFFIKAFP
QAVVSVRDALPPDFPQHIADAIFSHSLIMLERLRHKE

Download         Length: 1314 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9319.56 Da        Isoelectric Point: 5.0775

>AT265379 WP_010670157.1 NZ_CP113085:2878122-2878370 [Pantoea agglomerans]
MIYSPLQLANRLKLIRQRNGWTQSELAKKVGLKQATISHFENAPDSTSLATLFKLLQSLELSLEVQEKEEAGAPQVHDED
EW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References