Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 95537..96168 Replicon chromosome
Accession NZ_CP113085
Organism Pantoea agglomerans strain AB378

Toxin (Protein)


Gene name hicA Uniprot ID A0A7X5MR53
Locus tag OSE17_RS00440 Protein ID WP_010253953.1
Coordinates 95989..96168 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A8X8DTB6
Locus tag OSE17_RS00435 Protein ID WP_010253955.1
Coordinates 95537..95962 (-) Length 142 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSE17_RS00415 (OSE17_00415) 92258..92767 - 510 WP_010253965.1 phenolic acid decarboxylase -
OSE17_RS00420 (OSE17_00420) 92873..93772 + 900 WP_172608183.1 LysR family transcriptional regulator -
OSE17_RS00425 (OSE17_00425) 94200..95129 - 930 WP_191913914.1 Rpn family recombination-promoting nuclease/putative transposase -
OSE17_RS00430 (OSE17_00430) 95366..95483 - 118 Protein_81 subtype I-E CRISPR-associated endonuclease Cas1 -
OSE17_RS00435 (OSE17_00435) 95537..95962 - 426 WP_010253955.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OSE17_RS00440 (OSE17_00440) 95989..96168 - 180 WP_010253953.1 type II toxin-antitoxin system HicA family toxin Toxin
OSE17_RS00445 (OSE17_00445) 96351..97775 - 1425 WP_010253950.1 dihydrolipoyl dehydrogenase -
OSE17_RS00450 (OSE17_00450) 97936..99837 - 1902 WP_010671838.1 pyruvate dehydrogenase complex dihydrolipoyllysine-residue acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6467.52 Da        Isoelectric Point: 10.7891

>T265374 WP_010253953.1 NZ_CP113085:c96168-95989 [Pantoea agglomerans]
MDSSTLISEMKADGWVLTGINGSHHHFTHPTKPGLVTVPHPKKDLPIGTVKSIRKQARI

Download         Length: 180 bp

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15422.60 Da        Isoelectric Point: 4.7662

>AT265374 WP_010253955.1 NZ_CP113085:c95962-95537 [Pantoea agglomerans]
MFYPIAIEAGDHEHAYGVIVPDLPGCFSAGDTLDEAIKNAKEAITGHIELCVELGHEIPAVSTIETLATNPDYQGYIWAL
VDVDVIRLLGGSEKINVTLPRSLIDRIDRCVASHPEYKSRSGFLAQVALERITAPINRPQK

Download         Length: 426 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7X5MR53

Antitoxin

Source ID Structure

References