Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1820827..1822463 Replicon chromosome
Accession NZ_CP113073
Organism Acinetobacter baumannii strain A118 DeltaH0N27_10820::kan H0N27_10830-K176N

Toxin (Protein)


Gene name hipA Uniprot ID A0A8B4MZ76
Locus tag OSH17_RS08485 Protein ID WP_000737058.1
Coordinates 1820827..1822158 (+) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OSH17_RS08490 Protein ID WP_001101310.1
Coordinates 1822155..1822463 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSH17_RS08465 (OSH17_08465) 1817139..1818302 + 1164 WP_168726226.1 hypothetical protein -
OSH17_RS08470 (OSH17_08470) 1818429..1819400 + 972 WP_168726227.1 5'/3'-nucleotidase SurE -
OSH17_RS08475 (OSH17_08475) 1819412..1820056 + 645 WP_032000318.1 hypothetical protein -
OSH17_RS08480 (OSH17_08480) 1820091..1820531 - 441 WP_168726228.1 HD domain-containing protein -
OSH17_RS08485 (OSH17_08485) 1820827..1822158 + 1332 WP_000737058.1 HipA domain-containing protein Toxin
OSH17_RS08490 (OSH17_08490) 1822155..1822463 + 309 WP_001101310.1 helix-turn-helix domain-containing protein Antitoxin
OSH17_RS08495 (OSH17_08495) 1823186..1823734 + 549 WP_168726229.1 TetR/AcrR family transcriptional regulator -
OSH17_RS08500 (OSH17_08500) 1823852..1824850 + 999 WP_168726230.1 adenosine deaminase -
OSH17_RS08505 (OSH17_08505) 1824851..1825393 + 543 WP_168726231.1 non-canonical purine NTP pyrophosphatase -
OSH17_RS08510 (OSH17_08510) 1825390..1826226 + 837 WP_168726232.1 SIR2 family protein -
OSH17_RS08515 (OSH17_08515) 1826404..1826922 + 519 WP_168726233.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(167-359)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-83)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 51202.34 Da        Isoelectric Point: 4.9820

>T265359 WP_000737058.1 NZ_CP113073:1820827-1822158 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESNTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEKFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFNTIETTQM
KLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFICEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Download         Length: 1332 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11630.54 Da        Isoelectric Point: 9.9701

>AT265359 WP_001101310.1 NZ_CP113073:1822155-1822463 [Acinetobacter baumannii]
MNVKNQTQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4MZ76

Antitoxin

Source ID Structure

References