Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1820838..1822474 Replicon chromosome
Accession NZ_CP113072
Organism Acinetobacter baumannii strain A118 DeltaH0N27_10820-30::kan

Toxin (Protein)


Gene name hipA Uniprot ID A0A8B4MZ76
Locus tag OSH16_RS08485 Protein ID WP_000737058.1
Coordinates 1820838..1822169 (+) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OSH16_RS08490 Protein ID WP_001101310.1
Coordinates 1822166..1822474 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSH16_RS08465 (OSH16_08465) 1817150..1818313 + 1164 WP_168726226.1 hypothetical protein -
OSH16_RS08470 (OSH16_08470) 1818440..1819411 + 972 WP_168726227.1 5'/3'-nucleotidase SurE -
OSH16_RS08475 (OSH16_08475) 1819423..1820067 + 645 WP_032000318.1 hypothetical protein -
OSH16_RS08480 (OSH16_08480) 1820102..1820542 - 441 WP_168726228.1 HD domain-containing protein -
OSH16_RS08485 (OSH16_08485) 1820838..1822169 + 1332 WP_000737058.1 HipA domain-containing protein Toxin
OSH16_RS08490 (OSH16_08490) 1822166..1822474 + 309 WP_001101310.1 helix-turn-helix domain-containing protein Antitoxin
OSH16_RS08495 (OSH16_08495) 1823197..1823745 + 549 WP_168726229.1 TetR/AcrR family transcriptional regulator -
OSH16_RS08500 (OSH16_08500) 1823863..1824861 + 999 WP_168726230.1 adenosine deaminase -
OSH16_RS08505 (OSH16_08505) 1824862..1825404 + 543 WP_168726231.1 non-canonical purine NTP pyrophosphatase -
OSH16_RS08510 (OSH16_08510) 1825401..1826237 + 837 WP_168726232.1 SIR2 family protein -
OSH16_RS08515 (OSH16_08515) 1826415..1826933 + 519 WP_168726233.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(167-359)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-83)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 51202.34 Da        Isoelectric Point: 4.9820

>T265357 WP_000737058.1 NZ_CP113072:1820838-1822169 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESNTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEKFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFNTIETTQM
KLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFICEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Download         Length: 1332 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11630.54 Da        Isoelectric Point: 9.9701

>AT265357 WP_001101310.1 NZ_CP113072:1822166-1822474 [Acinetobacter baumannii]
MNVKNQTQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4MZ76

Antitoxin

Source ID Structure

References