Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1929671..1931307 Replicon chromosome
Accession NZ_CP113070
Organism Acinetobacter baumannii strain A118 DeltaH0N27_10825::kan

Toxin (Protein)


Gene name hipA Uniprot ID A0A8B4MZ76
Locus tag OSH13_RS09090 Protein ID WP_000737058.1
Coordinates 1929976..1931307 (-) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OSH13_RS09085 Protein ID WP_001101310.1
Coordinates 1929671..1929979 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSH13_RS09060 (OSH13_09060) 1925212..1925730 - 519 WP_168726233.1 GNAT family N-acetyltransferase -
OSH13_RS09065 (OSH13_09065) 1925908..1926744 - 837 WP_168726232.1 SIR2 family protein -
OSH13_RS09070 (OSH13_09070) 1926741..1927283 - 543 WP_168726231.1 non-canonical purine NTP pyrophosphatase -
OSH13_RS09075 (OSH13_09075) 1927284..1928282 - 999 WP_168726230.1 adenosine deaminase -
OSH13_RS09080 (OSH13_09080) 1928400..1928948 - 549 WP_168726229.1 TetR/AcrR family transcriptional regulator -
OSH13_RS09085 (OSH13_09085) 1929671..1929979 - 309 WP_001101310.1 helix-turn-helix domain-containing protein Antitoxin
OSH13_RS09090 (OSH13_09090) 1929976..1931307 - 1332 WP_000737058.1 HipA domain-containing protein Toxin
OSH13_RS09095 (OSH13_09095) 1931603..1932043 + 441 WP_168726228.1 HD domain-containing protein -
OSH13_RS09100 (OSH13_09100) 1932078..1932722 - 645 WP_032000318.1 hypothetical protein -
OSH13_RS09105 (OSH13_09105) 1932734..1933705 - 972 WP_168726227.1 5'/3'-nucleotidase SurE -
OSH13_RS09110 (OSH13_09110) 1933832..1934995 - 1164 WP_168726226.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(167-359)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-83)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 51202.34 Da        Isoelectric Point: 4.9820

>T265352 WP_000737058.1 NZ_CP113070:c1931307-1929976 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESNTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEKFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFNTIETTQM
KLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFICEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Download         Length: 1332 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11630.54 Da        Isoelectric Point: 9.9701

>AT265352 WP_001101310.1 NZ_CP113070:c1929979-1929671 [Acinetobacter baumannii]
MNVKNQTQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4MZ76

Antitoxin

Source ID Structure

References