Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 271026..271540 Replicon chromosome
Accession NZ_CP113052
Organism Staphylococcus aureus strain Fizz

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag OS084_RS01640 Protein ID WP_000581792.1
Coordinates 271026..271235 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag OS084_RS01645 Protein ID WP_000138932.1
Coordinates 271247..271540 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS084_RS01620 (266534) 266534..267892 - 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
OS084_RS01625 (267907) 267907..268977 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
OS084_RS01630 (269295) 269295..270497 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
OS084_RS01635 (270761) 270761..270898 - 138 WP_000828354.1 Lmo0850 family protein -
OS084_RS01640 (271026) 271026..271235 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
OS084_RS01645 (271247) 271247..271540 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
OS084_RS01650 (271706) 271706..273190 + 1485 WP_000571549.1 cardiolipin synthase -
OS084_RS01655 (273218) 273218..273865 + 648 WP_001187629.1 HD domain-containing protein -
OS084_RS01660 (274678) 274678..275550 - 873 WP_000725802.1 membrane protein insertase YidC -
OS084_RS01665 (275636) 275636..276277 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T265344 WP_000581792.1 NZ_CP113052:c271235-271026 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT265344 WP_000138932.1 NZ_CP113052:c271540-271247 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References