265343

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 251270..251799 Replicon chromosome
Accession NZ_CP113052
Organism Staphylococcus aureus strain Fizz

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag OS084_RS01550 Protein ID WP_000621175.1
Coordinates 251270..251632 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag OS084_RS01555 Protein ID WP_000948331.1
Coordinates 251629..251799 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS084_RS01530 (248248) 248248..249018 - 771 WP_001041103.1 RNA polymerase sigma factor SigB -
OS084_RS01535 (248993) 248993..249472 - 480 WP_001190829.1 anti-sigma B factor RsbW -
OS084_RS01540 (249474) 249474..249800 - 327 WP_001052491.1 anti-sigma factor antagonist -
OS084_RS01545 (249919) 249919..250920 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
OS084_RS01550 (251270) 251270..251632 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OS084_RS01555 (251629) 251629..251799 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
OS084_RS01560 (251884) 251884..253032 - 1149 WP_001281145.1 alanine racemase -
OS084_RS01565 (253098) 253098..253457 - 360 WP_000581200.1 holo-ACP synthase -
OS084_RS01570 (253461) 253461..253952 - 492 WP_267838006.1 PH domain-containing protein -
OS084_RS01575 (253939) 253939..255522 - 1584 WP_001294626.1 PH domain-containing protein -
OS084_RS01580 (255515) 255515..255994 - 480 WP_001287088.1 hypothetical protein -
OS084_RS01585 (256202) 256202..256762 - 561 WP_001092411.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T265343 WP_000621175.1 NZ_CP113052:c251632-251270 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT265343 WP_000948331.1 NZ_CP113052:c251799-251629 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References