Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 50573..51349 Replicon chromosome
Accession NZ_CP113052
Organism Staphylococcus aureus strain Fizz

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag OS084_RS00285 Protein ID WP_000031108.1
Coordinates 50573..50725 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag OS084_RS00290 Protein ID WP_001251224.1
Coordinates 50750..51349 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS084_RS00270 (46536) 46536..47357 + 822 WP_000669376.1 RluA family pseudouridine synthase -
OS084_RS00275 (47820) 47820..49205 - 1386 WP_000116224.1 class II fumarate hydratase -
OS084_RS00280 (49401) 49401..49796 - 396 WP_000901021.1 hypothetical protein -
OS084_RS00285 (50573) 50573..50725 - 153 WP_000031108.1 SAS053 family protein Toxin
OS084_RS00290 (50750) 50750..51349 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
OS084_RS00295 (51508) 51508..51978 - 471 WP_000181398.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
OS084_RS00300 (51983) 51983..53110 - 1128 WP_000379978.1 tRNA epoxyqueuosine(34) reductase QueG -
OS084_RS00305 (53261) 53261..53983 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
OS084_RS00310 (53976) 53976..55433 - 1458 WP_267838003.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T265339 WP_000031108.1 NZ_CP113052:c50725-50573 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT265339 WP_001251224.1 NZ_CP113052:c51349-50750 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References