Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1776691..1777205 Replicon chromosome
Accession NZ_CP113051
Organism Staphylococcus aureus strain Viktor

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag OS088_RS09125 Protein ID WP_000581792.1
Coordinates 1776691..1776900 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag OS088_RS09130 Protein ID WP_000138932.1
Coordinates 1776912..1777205 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS088_RS09105 (1772199) 1772199..1773557 - 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
OS088_RS09110 (1773572) 1773572..1774642 - 1071 WP_000159632.1 D-alanine--D-alanine ligase -
OS088_RS09115 (1774960) 1774960..1776162 + 1203 WP_001109944.1 FtsW/RodA/SpoVE family cell cycle protein -
OS088_RS09120 (1776426) 1776426..1776563 - 138 WP_000828354.1 Lmo0850 family protein -
OS088_RS09125 (1776691) 1776691..1776900 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
OS088_RS09130 (1776912) 1776912..1777205 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
OS088_RS09135 (1777371) 1777371..1778855 + 1485 WP_000571549.1 cardiolipin synthase -
OS088_RS09140 (1778883) 1778883..1779530 + 648 WP_154283800.1 HD domain-containing protein -
OS088_RS09145 (1779590) 1779590..1779859 - 270 WP_195758892.1 hypothetical protein -
OS088_RS09150 (1780310) 1780310..1781182 - 873 WP_154283799.1 membrane protein insertase YidC -
OS088_RS09155 (1781268) 1781268..1781909 - 642 WP_154283798.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T265334 WP_000581792.1 NZ_CP113051:c1776900-1776691 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT265334 WP_000138932.1 NZ_CP113051:c1777205-1776912 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References