Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1756935..1757464 Replicon chromosome
Accession NZ_CP113051
Organism Staphylococcus aureus strain Viktor

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag OS088_RS09035 Protein ID WP_000621175.1
Coordinates 1756935..1757297 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag OS088_RS09040 Protein ID WP_000948330.1
Coordinates 1757294..1757464 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS088_RS09015 (1753915) 1753915..1754685 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
OS088_RS09020 (1754660) 1754660..1755139 - 480 WP_001190825.1 anti-sigma B factor RsbW -
OS088_RS09025 (1755141) 1755141..1755467 - 327 WP_001052491.1 anti-sigma factor antagonist -
OS088_RS09030 (1755586) 1755586..1756587 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
OS088_RS09035 (1756935) 1756935..1757297 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OS088_RS09040 (1757294) 1757294..1757464 - 171 WP_000948330.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
OS088_RS09045 (1757549) 1757549..1758697 - 1149 WP_001281148.1 alanine racemase -
OS088_RS09050 (1758763) 1758763..1759122 - 360 WP_000581193.1 holo-ACP synthase -
OS088_RS09055 (1759126) 1759126..1759617 - 492 WP_154283807.1 PH domain-containing protein -
OS088_RS09060 (1759604) 1759604..1761187 - 1584 WP_209205797.1 PH domain-containing protein -
OS088_RS09065 (1761180) 1761180..1761659 - 480 WP_154283805.1 hypothetical protein -
OS088_RS09070 (1761868) 1761868..1762428 - 561 WP_154283804.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T265333 WP_000621175.1 NZ_CP113051:c1757297-1756935 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6237.75 Da        Isoelectric Point: 3.8305

>AT265333 WP_000948330.1 NZ_CP113051:c1757464-1757294 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNESYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References