Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1543285..1544061 Replicon chromosome
Accession NZ_CP113051
Organism Staphylococcus aureus strain Viktor

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag OS088_RS07735 Protein ID WP_000031108.1
Coordinates 1543285..1543437 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag OS088_RS07740 Protein ID WP_154284644.1
Coordinates 1543462..1544061 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS088_RS07720 (1539733) 1539733..1540128 - 396 WP_000901023.1 hypothetical protein -
OS088_RS07725 (1541013) 1541013..1541774 - 762 WP_001066123.1 IS21-like element helper ATPase IstB -
OS088_RS07730 (1541767) 1541767..1543059 - 1293 WP_267814037.1 IS21 family transposase -
OS088_RS07735 (1543285) 1543285..1543437 - 153 WP_000031108.1 SAS053 family protein Toxin
OS088_RS07740 (1543462) 1543462..1544061 - 600 WP_154284644.1 glucosamine-6-phosphate isomerase Antitoxin
OS088_RS07745 (1544220) 1544220..1544690 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
OS088_RS07750 (1544695) 1544695..1545822 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
OS088_RS07755 (1545972) 1545972..1546694 - 723 WP_209206048.1 amino acid ABC transporter ATP-binding protein -
OS088_RS07760 (1546687) 1546687..1548144 - 1458 WP_154284642.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1541013..1541777 764


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T265328 WP_000031108.1 NZ_CP113051:c1543437-1543285 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT265328 WP_154284644.1 NZ_CP113051:c1544061-1543462 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNISIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure

References