Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 2866525..2867301 Replicon chromosome
Accession NZ_CP113049
Organism Staphylococcus aureus strain Ahri

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag OS089_RS14320 Protein ID WP_000031108.1
Coordinates 2867149..2867301 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A6B1RP77
Locus tag OS089_RS14315 Protein ID WP_001251218.1
Coordinates 2866525..2867124 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS089_RS14295 (2862441) 2862441..2863898 + 1458 WP_000649908.1 ABC transporter permease subunit -
OS089_RS14300 (2863891) 2863891..2864613 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
OS089_RS14305 (2864764) 2864764..2865891 + 1128 WP_000379977.1 tRNA epoxyqueuosine(34) reductase QueG -
OS089_RS14310 (2865896) 2865896..2866366 + 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
OS089_RS14315 (2866525) 2866525..2867124 + 600 WP_001251218.1 glucosamine-6-phosphate isomerase Antitoxin
OS089_RS14320 (2867149) 2867149..2867301 + 153 WP_000031108.1 SAS053 family protein Toxin
OS089_RS14325 (2867964) 2867964..2868359 + 396 WP_000901022.1 hypothetical protein -
OS089_RS14330 (2868555) 2868555..2869940 + 1386 WP_000116233.1 class II fumarate hydratase -
OS089_RS14335 (2870405) 2870405..2871226 - 822 WP_000669384.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T265323 WP_000031108.1 NZ_CP113049:2867149-2867301 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT265323 WP_001251218.1 NZ_CP113049:2866525-2867124 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFIVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A6B1RP77

References