265322

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2714564..2715093 Replicon chromosome
Accession NZ_CP113049
Organism Staphylococcus aureus strain Ahri

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag OS089_RS13445 Protein ID WP_000621175.1
Coordinates 2714731..2715093 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag OS089_RS13440 Protein ID WP_000948331.1
Coordinates 2714564..2714734 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS089_RS13410 (2709600) 2709600..2710160 + 561 WP_001092405.1 K(+)-transporting ATPase subunit C -
OS089_RS13415 (2710369) 2710369..2710848 + 480 WP_001287083.1 hypothetical protein -
OS089_RS13420 (2710841) 2710841..2712424 + 1584 WP_267813953.1 PH domain-containing protein -
OS089_RS13425 (2712411) 2712411..2712902 + 492 WP_001205915.1 PH domain-containing protein -
OS089_RS13430 (2712906) 2712906..2713265 + 360 WP_000581194.1 holo-ACP synthase -
OS089_RS13435 (2713331) 2713331..2714479 + 1149 WP_001280702.1 alanine racemase -
OS089_RS13440 (2714564) 2714564..2714734 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
OS089_RS13445 (2714731) 2714731..2715093 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OS089_RS13450 (2715442) 2715442..2716443 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
OS089_RS13455 (2716562) 2716562..2716888 + 327 WP_001052491.1 anti-sigma factor antagonist -
OS089_RS13460 (2716890) 2716890..2717369 + 480 WP_001190825.1 anti-sigma B factor RsbW -
OS089_RS13465 (2717344) 2717344..2718114 + 771 WP_001041107.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T265322 WP_000621175.1 NZ_CP113049:2714731-2715093 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT265322 WP_000948331.1 NZ_CP113049:2714564-2714734 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References