Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 399313..399827 Replicon chromosome
Accession NZ_CP113047
Organism Staphylococcus aureus strain Sett

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag OS087_RS02230 Protein ID WP_000581792.1
Coordinates 399313..399522 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag OS087_RS02235 Protein ID WP_000138932.1
Coordinates 399534..399827 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS087_RS02210 (394821) 394821..396179 - 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
OS087_RS02215 (396194) 396194..397264 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
OS087_RS02220 (397582) 397582..398784 + 1203 WP_267811092.1 FtsW/RodA/SpoVE family cell cycle protein -
OS087_RS02225 (399048) 399048..399185 - 138 WP_000828354.1 Lmo0850 family protein -
OS087_RS02230 (399313) 399313..399522 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
OS087_RS02235 (399534) 399534..399827 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
OS087_RS02240 (399993) 399993..401477 + 1485 WP_000571549.1 cardiolipin synthase -
OS087_RS02245 (401505) 401505..402152 + 648 WP_001187630.1 HD domain-containing protein -
OS087_RS02250 (402864) 402864..403736 - 873 WP_000725800.1 membrane protein insertase YidC -
OS087_RS02255 (403822) 403822..404463 - 642 WP_000483156.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T265304 WP_000581792.1 NZ_CP113047:c399522-399313 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT265304 WP_000138932.1 NZ_CP113047:c399827-399534 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References