265303

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 379554..380083 Replicon chromosome
Accession NZ_CP113047
Organism Staphylococcus aureus strain Sett

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag OS087_RS02140 Protein ID WP_000621175.1
Coordinates 379554..379916 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag OS087_RS02145 Protein ID WP_000948331.1
Coordinates 379913..380083 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS087_RS02120 (376533) 376533..377303 - 771 WP_001041103.1 RNA polymerase sigma factor SigB -
OS087_RS02125 (377278) 377278..377757 - 480 WP_001190829.1 anti-sigma B factor RsbW -
OS087_RS02130 (377759) 377759..378085 - 327 WP_050970665.1 anti-sigma factor antagonist -
OS087_RS02135 (378204) 378204..379205 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
OS087_RS02140 (379554) 379554..379916 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OS087_RS02145 (379913) 379913..380083 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
OS087_RS02150 (380168) 380168..381316 - 1149 WP_001281154.1 alanine racemase -
OS087_RS02155 (381382) 381382..381741 - 360 WP_000581197.1 holo-ACP synthase -
OS087_RS02160 (381745) 381745..382236 - 492 WP_001205912.1 PH domain-containing protein -
OS087_RS02165 (382223) 382223..383807 - 1585 Protein_388 PH domain-containing protein -
OS087_RS02170 (383800) 383800..384279 - 480 WP_001287079.1 hypothetical protein -
OS087_RS02175 (384488) 384488..385048 - 561 WP_001092409.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T265303 WP_000621175.1 NZ_CP113047:c379916-379554 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT265303 WP_000948331.1 NZ_CP113047:c380083-379913 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References