Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 182855..183631 Replicon chromosome
Accession NZ_CP113047
Organism Staphylococcus aureus strain Sett

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag OS087_RS00880 Protein ID WP_000031108.1
Coordinates 182855..183007 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag OS087_RS00885 Protein ID WP_001251224.1
Coordinates 183032..183631 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS087_RS00865 (179058) 179058..179879 + 822 WP_000669376.1 RluA family pseudouridine synthase -
OS087_RS00870 (180331) 180331..181716 - 1386 WP_000116229.1 class II fumarate hydratase -
OS087_RS00875 (181912) 181912..182307 - 396 WP_086353413.1 hypothetical protein -
OS087_RS00880 (182855) 182855..183007 - 153 WP_000031108.1 SAS053 family protein Toxin
OS087_RS00885 (183032) 183032..183631 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
OS087_RS00890 (183790) 183790..184260 - 471 WP_049311634.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
OS087_RS00895 (184265) 184265..185392 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
OS087_RS00900 (185543) 185543..186265 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
OS087_RS00905 (186258) 186258..187715 - 1458 WP_000649908.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T265298 WP_000031108.1 NZ_CP113047:c183007-182855 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT265298 WP_001251224.1 NZ_CP113047:c183631-183032 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References