Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 2867156..2867932 Replicon chromosome
Accession NZ_CP113044
Organism Staphylococcus aureus strain LeBlanc

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag OS085_RS14290 Protein ID WP_000031108.1
Coordinates 2867156..2867308 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag OS085_RS14295 Protein ID WP_001251224.1
Coordinates 2867333..2867932 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS085_RS14275 (2863119) 2863119..2863940 + 822 WP_000669376.1 RluA family pseudouridine synthase -
OS085_RS14280 (2864403) 2864403..2865788 - 1386 WP_000116224.1 class II fumarate hydratase -
OS085_RS14285 (2865984) 2865984..2866379 - 396 WP_000901021.1 hypothetical protein -
OS085_RS14290 (2867156) 2867156..2867308 - 153 WP_000031108.1 SAS053 family protein Toxin
OS085_RS14295 (2867333) 2867333..2867932 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
OS085_RS14300 (2868091) 2868091..2868561 - 471 WP_000181398.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
OS085_RS14305 (2868566) 2868566..2869693 - 1128 WP_000379978.1 tRNA epoxyqueuosine(34) reductase QueG -
OS085_RS14310 (2869844) 2869844..2870566 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
OS085_RS14315 (2870559) 2870559..2872016 - 1458 WP_000649907.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T265296 WP_000031108.1 NZ_CP113044:c2867308-2867156 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT265296 WP_001251224.1 NZ_CP113044:c2867932-2867333 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References