265294

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1762803..1763280 Replicon chromosome
Accession NZ_CP113044
Organism Staphylococcus aureus strain LeBlanc

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag OS085_RS08835 Protein ID WP_000052078.1
Coordinates 1762803..1762991 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag OS085_RS08840 Protein ID WP_001059690.1
Coordinates 1763020..1763280 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS085_RS08805 (1758844) 1758844..1759314 + 471 WP_000824472.1 hypothetical protein -
OS085_RS08810 (1759655) 1759655..1760341 + 687 WP_001548082.1 thermonuclease family protein -
OS085_RS08815 (1760698) 1760698..1760898 + 201 WP_001059082.1 cold-shock protein -
OS085_RS08820 (1761394) 1761394..1761612 - 219 WP_000005886.1 hypothetical protein -
OS085_RS08825 (1761674) 1761674..1761958 - 285 WP_001004395.1 hypothetical protein -
OS085_RS08830 (1762046) 1762046..1762615 - 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
OS085_RS08835 (1762803) 1762803..1762991 - 189 WP_000052078.1 hypothetical protein Toxin
OS085_RS08840 (1763020) 1763020..1763280 - 261 WP_001059690.1 hypothetical protein Antitoxin
OS085_RS08845 (1763621) 1763621..1763824 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
OS085_RS08850 (1763821) 1763821..1764057 - 237 WP_000368687.1 hypothetical protein -
OS085_RS08855 (1764282) 1764282..1764863 + 582 WP_001140686.1 histidine phosphatase family protein -
OS085_RS08860 (1764936) 1764936..1765553 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
OS085_RS08865 (1765708) 1765708..1766202 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
OS085_RS08870 (1766601) 1766601..1767023 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
OS085_RS08875 (1767171) 1767171..1767887 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selq 1757487..1788569 31082


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T265294 WP_000052078.1 NZ_CP113044:c1762991-1762803 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT265294 WP_001059690.1 NZ_CP113044:c1763280-1763020 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References