Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 209883..210397 Replicon chromosome
Accession NZ_CP113044
Organism Staphylococcus aureus strain LeBlanc

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag OS085_RS01185 Protein ID WP_000581792.1
Coordinates 209883..210092 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag OS085_RS01190 Protein ID WP_000138932.1
Coordinates 210104..210397 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS085_RS01165 (205391) 205391..206749 - 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
OS085_RS01170 (206764) 206764..207834 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
OS085_RS01175 (208152) 208152..209354 + 1203 WP_267811092.1 FtsW/RodA/SpoVE family cell cycle protein -
OS085_RS01180 (209618) 209618..209755 - 138 WP_000828354.1 Lmo0850 family protein -
OS085_RS01185 (209883) 209883..210092 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
OS085_RS01190 (210104) 210104..210397 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
OS085_RS01195 (210563) 210563..212047 + 1485 WP_000571549.1 cardiolipin synthase -
OS085_RS01200 (212075) 212075..212722 + 648 WP_001187629.1 HD domain-containing protein -
OS085_RS01205 (213535) 213535..214407 - 873 WP_267836553.1 membrane protein insertase YidC -
OS085_RS01210 (214493) 214493..215134 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T265289 WP_000581792.1 NZ_CP113044:c210092-209883 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT265289 WP_000138932.1 NZ_CP113044:c210397-210104 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References