Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 190127..190656 Replicon chromosome
Accession NZ_CP113044
Organism Staphylococcus aureus strain LeBlanc

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag OS085_RS01095 Protein ID WP_000621175.1
Coordinates 190127..190489 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag OS085_RS01100 Protein ID WP_000948331.1
Coordinates 190486..190656 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS085_RS01075 (187105) 187105..187875 - 771 WP_001041103.1 RNA polymerase sigma factor SigB -
OS085_RS01080 (187850) 187850..188329 - 480 WP_001190829.1 anti-sigma B factor RsbW -
OS085_RS01085 (188331) 188331..188657 - 327 WP_001052491.1 anti-sigma factor antagonist -
OS085_RS01090 (188776) 188776..189777 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
OS085_RS01095 (190127) 190127..190489 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OS085_RS01100 (190486) 190486..190656 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
OS085_RS01105 (190741) 190741..191889 - 1149 WP_001281145.1 alanine racemase -
OS085_RS01110 (191955) 191955..192314 - 360 WP_000581200.1 holo-ACP synthase -
OS085_RS01115 (192318) 192318..192809 - 492 WP_001205910.1 PH domain-containing protein -
OS085_RS01120 (192796) 192796..194379 - 1584 WP_001294626.1 PH domain-containing protein -
OS085_RS01125 (194372) 194372..194851 - 480 WP_001287088.1 hypothetical protein -
OS085_RS01130 (195059) 195059..195619 - 561 WP_001092411.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T265288 WP_000621175.1 NZ_CP113044:c190489-190127 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT265288 WP_000948331.1 NZ_CP113044:c190656-190486 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References