265284

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 2910898..2911674 Replicon chromosome
Accession NZ_CP113042
Organism Staphylococcus aureus strain Seraphine

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag OS079_RS14625 Protein ID WP_000031108.1
Coordinates 2910898..2911050 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag OS079_RS14630 Protein ID WP_001251224.1
Coordinates 2911075..2911674 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS079_RS14610 (2906861) 2906861..2907682 + 822 WP_000669376.1 RluA family pseudouridine synthase -
OS079_RS14615 (2908145) 2908145..2909530 - 1386 WP_000116224.1 class II fumarate hydratase -
OS079_RS14620 (2909726) 2909726..2910121 - 396 WP_000901021.1 hypothetical protein -
OS079_RS14625 (2910898) 2910898..2911050 - 153 WP_000031108.1 SAS053 family protein Toxin
OS079_RS14630 (2911075) 2911075..2911674 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
OS079_RS14635 (2911833) 2911833..2912303 - 471 WP_000181398.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
OS079_RS14640 (2912308) 2912308..2913435 - 1128 WP_000379978.1 tRNA epoxyqueuosine(34) reductase QueG -
OS079_RS14645 (2913586) 2913586..2914308 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
OS079_RS14650 (2914301) 2914301..2915758 - 1458 WP_000649907.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T265284 WP_000031108.1 NZ_CP113042:c2911050-2910898 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT265284 WP_001251224.1 NZ_CP113042:c2911674-2911075 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References