Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 839141..839664 Replicon chromosome
Accession NZ_CP113039
Organism Staphylococcus aureus strain Gwen

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag OS086_RS04520 Protein ID WP_000074049.1
Coordinates 839141..839407 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag OS086_RS04525 Protein ID WP_000587616.1
Coordinates 839407..839664 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS086_RS04500 (834448) 834448..835635 - 1188 WP_000026189.1 MFS transporter -
OS086_RS04505 (836031) 836031..836807 - 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
OS086_RS04510 (836800) 836800..837462 - 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
OS086_RS04515 (837710) 837710..838786 - 1077 WP_001076673.1 M42 family metallopeptidase -
OS086_RS04520 (839141) 839141..839407 - 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
OS086_RS04525 (839407) 839407..839664 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OS086_RS04530 (840023) 840023..840478 + 456 WP_267811115.1 DUF1307 domain-containing protein -
OS086_RS04535 (840646) 840646..842223 - 1578 WP_267811116.1 FMN-binding glutamate synthase family protein -
OS086_RS04540 (842418) 842418..843167 + 750 WP_000072461.1 CPBP family lipoprotein N-acylation protein LnsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T265266 WP_000074049.1 NZ_CP113039:c839407-839141 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT265266 WP_000587616.1 NZ_CP113039:c839664-839407 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References