265261

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 466008..466522 Replicon chromosome
Accession NZ_CP113039
Organism Staphylococcus aureus strain Gwen

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag OS086_RS02560 Protein ID WP_000581792.1
Coordinates 466008..466217 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag OS086_RS02565 Protein ID WP_000138932.1
Coordinates 466229..466522 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS086_RS02540 (461516) 461516..462874 - 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
OS086_RS02545 (462889) 462889..463959 - 1071 WP_042109557.1 D-alanine--D-alanine ligase -
OS086_RS02550 (464277) 464277..465479 + 1203 WP_267811092.1 FtsW/RodA/SpoVE family cell cycle protein -
OS086_RS02555 (465743) 465743..465880 - 138 WP_000828354.1 Lmo0850 family protein -
OS086_RS02560 (466008) 466008..466217 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
OS086_RS02565 (466229) 466229..466522 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
OS086_RS02570 (466688) 466688..468172 + 1485 WP_000571549.1 cardiolipin synthase -
OS086_RS02575 (468200) 468200..468847 + 648 WP_001187630.1 HD domain-containing protein -
OS086_RS02580 (469760) 469760..470632 - 873 WP_267811093.1 membrane protein insertase YidC -
OS086_RS02585 (470718) 470718..471359 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T265261 WP_000581792.1 NZ_CP113039:c466217-466008 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT265261 WP_000138932.1 NZ_CP113039:c466522-466229 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References