265260

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 444749..445278 Replicon chromosome
Accession NZ_CP113039
Organism Staphylococcus aureus strain Gwen

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag OS086_RS02460 Protein ID WP_000621175.1
Coordinates 444749..445111 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag OS086_RS02465 Protein ID WP_000948331.1
Coordinates 445108..445278 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS086_RS02440 (441727) 441727..442497 - 771 WP_001041111.1 RNA polymerase sigma factor SigB -
OS086_RS02445 (442472) 442472..442951 - 480 WP_001190829.1 anti-sigma B factor RsbW -
OS086_RS02450 (442953) 442953..443279 - 327 WP_001052491.1 anti-sigma factor antagonist -
OS086_RS02455 (443398) 443398..444399 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
OS086_RS02460 (444749) 444749..445111 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OS086_RS02465 (445108) 445108..445278 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
OS086_RS02470 (445363) 445363..446511 - 1149 WP_001281154.1 alanine racemase -
OS086_RS02475 (446577) 446577..446936 - 360 WP_000581197.1 holo-ACP synthase -
OS086_RS02480 (446940) 446940..447431 - 492 WP_001205912.1 PH domain-containing protein -
OS086_RS02485 (447418) 447418..449001 - 1584 WP_001294626.1 PH domain-containing protein -
OS086_RS02490 (448994) 448994..449473 - 480 WP_001287087.1 hypothetical protein -
OS086_RS02495 (449681) 449681..450241 - 561 WP_001092411.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T265260 WP_000621175.1 NZ_CP113039:c445111-444749 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT265260 WP_000948331.1 NZ_CP113039:c445278-445108 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References