Detailed information of TA system TA026525

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-Xre
• Location: 957045..957977
• Replicon: plasmid pSmeSM11d
• Accession: NC_017326
• Organism: Sinorhizobium meliloti SM11

Toxin (Protein)

• Gene name: -
• Uniprot ID: F7XGP1
• Locus tag: SM11_RS31170
• Protein ID: WP_014530511.1
• Coordinates: 957045..957599 (-)
• Length: 185 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: F7XGP2
• Locus tag: SM11_RS31175
• Protein ID: WP_014530512.1
• Coordinates: 957606..957977 (-)
• Length: 124 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SM11_RS31155	952938..954306	+	1369	Protein_852	FAD-binding oxidoreductase	-
SM11_RS31160	954391..954879	-	489	Protein_853	IS630-like element ISRm2011-2 family transposase	-
SM11_RS31165	954960..956219	-	1260	WP_010975503.1	group II intron reverse transcriptase/maturase	-
SM11_RS39795	956767..957046	-	280	Protein_855	transposase	-
SM11_RS31170	957045..957599	-	555	WP_014530511.1	RES family NAD+ phosphorylase	Toxin
SM11_RS31175	957606..957977	-	372	WP_014530512.1	DUF2384 domain-containing protein	Antitoxin
SM11_RS31180	958054..958839	-	786	WP_014530513.1	crotonase/enoyl-CoA hydratase family protein	-
SM11_RS31185	958836..959705	-	870	WP_014530514.1	hydroxymethylglutaryl-CoA lyase	-
SM11_RS31190	959702..961690	-	1989	WP_014530515.1	acetyl/propionyl/methylcrotonyl-CoA carboxylase subunit alpha	-
SM11_RS31195	961707..962090	-	384	WP_014530516.1	RidA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	htpB	1..1632395	1632395

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (23-177)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (71-120)

Sequences

Toxin

Protein

• Length: 185 a.a.
• Molecular weight: 20449.31 Da
• Isoelectric Point: 6.4901

>T26525 WP_014530511.1 NC_017326:c957599-957045 [Sinorhizobium meliloti SM11]
MRKHIPPASRPDSEPTSPVEPITLWRAFVPRWAHMPLSGAGAARFGGRWNPIGMPAIYAARELSTAWAEYNQGFVQHPAL
IVQLELRGARLADLTDASVLLELGVDEAIHRCEWRDALDKGAVPETHRLQSELLARDYHGVIYPSFMSPGGTCVALWRWN
GAEEPRLDVIDPDGRLPKSPASWV

Nucleotide

• Length: 555 bp

>T26525 NC_017326:c957599-957045 [Sinorhizobium meliloti SM11]
ATGAGGAAACACATTCCGCCCGCATCGCGACCCGATTCGGAACCGACGTCGCCGGTCGAGCCGATAACGCTCTGGCGCGC
CTTCGTTCCGCGCTGGGCACATATGCCGCTATCCGGCGCGGGTGCCGCTCGCTTCGGTGGCCGCTGGAACCCGATCGGCA
TGCCTGCGATTTATGCTGCGCGCGAGCTTTCCACTGCCTGGGCTGAATATAATCAGGGTTTCGTCCAGCATCCGGCGCTC
ATCGTGCAGCTCGAGTTACGCGGGGCGAGGCTCGCGGACCTCACGGATGCCAGCGTTCTTCTGGAGCTTGGTGTAGATGA
GGCGATCCATCGCTGCGAATGGCGTGATGCGCTCGACAAAGGCGCGGTGCCGGAGACCCACAGGCTGCAGTCGGAGCTTC
TGGCGCGCGACTATCACGGGGTGATCTATCCATCCTTCATGTCGCCCGGCGGCACCTGCGTCGCGCTCTGGCGCTGGAAC
GGTGCGGAAGAACCGCGTCTCGACGTCATCGATCCCGATGGCCGGCTGCCGAAATCGCCCGCTTCATGGGTTTGA

Antitoxin

Protein

• Length: 124 a.a.
• Molecular weight: 13117.25 Da
• Isoelectric Point: 9.6233

>AT26525 WP_014530512.1 NC_017326:c957977-957606 [Sinorhizobium meliloti SM11]
MMAVDFQIAAARFGDDHSPFLSARLVADWLGVTLAELAKLIGVARNTLTAKSGARKVDSALSKVVRILAMASEMAGDEAR
AVIWFKHQPIPGWAGKTAFDLVGEGKADKVLAYLESVRAGVYA

Nucleotide

• Length: 372 bp

>AT26525 NC_017326:c957977-957606 [Sinorhizobium meliloti SM11]
ATGATGGCCGTTGATTTCCAGATAGCTGCAGCCCGTTTCGGGGACGATCATTCCCCGTTTCTCTCGGCCCGCCTTGTCGC
CGACTGGTTGGGCGTCACGCTCGCCGAACTCGCCAAGCTGATCGGTGTCGCCCGCAATACGCTGACGGCGAAATCCGGCG
CCCGGAAGGTCGACAGCGCCTTGAGCAAGGTCGTCCGCATCCTCGCCATGGCTTCCGAAATGGCGGGCGACGAAGCCCGC
GCCGTCATCTGGTTCAAGCACCAGCCTATCCCCGGCTGGGCCGGCAAGACGGCGTTCGATCTGGTCGGCGAGGGCAAGGC
CGACAAGGTGCTCGCCTATCTCGAATCGGTACGTGCCGGCGTCTACGCTTAA

Structures

Toxin

• AlphaFold DB: A0A222K2B4

Antitoxin

• AlphaFold DB: A0A222K374