Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1109474..1110003 Replicon chromosome
Accession NZ_CP113037
Organism Staphylococcus aureus strain Zilean

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag OS091_RS05670 Protein ID WP_000621175.1
Coordinates 1109641..1110003 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag OS091_RS05665 Protein ID WP_000948331.1
Coordinates 1109474..1109644 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS091_RS05635 1104510..1105070 + 561 WP_001092405.1 K(+)-transporting ATPase subunit C -
OS091_RS05640 1105279..1105758 + 480 WP_267842146.1 hypothetical protein -
OS091_RS05645 1105751..1107334 + 1584 WP_001294642.1 PH domain-containing protein -
OS091_RS05650 1107321..1107812 + 492 WP_001205915.1 PH domain-containing protein -
OS091_RS05655 1107816..1108175 + 360 WP_000581194.1 holo-ACP synthase -
OS091_RS05660 1108241..1109389 + 1149 WP_001280702.1 alanine racemase -
OS091_RS05665 1109474..1109644 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
OS091_RS05670 1109641..1110003 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OS091_RS05675 1110352..1111353 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
OS091_RS05680 1111472..1111798 + 327 WP_001052491.1 anti-sigma factor antagonist -
OS091_RS05685 1111800..1112279 + 480 WP_001190825.1 anti-sigma B factor RsbW -
OS091_RS05690 1112254..1113024 + 771 WP_001041107.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T265248 WP_000621175.1 NZ_CP113037:1109641-1110003 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT265248 WP_000948331.1 NZ_CP113037:1109474-1109644 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References