265241

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Xre-MNT/HTH_26(antitoxin)
Location 543413..544521 Replicon chromosome
Accession NZ_CP113037
Organism Staphylococcus aureus strain Zilean

Toxin (Protein)


Gene name MNTss Uniprot ID R3JIN1
Locus tag OS091_RS02800 Protein ID WP_000233000.1
Coordinates 543652..544521 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name Xress Uniprot ID -
Locus tag OS091_RS02795 Protein ID WP_000205227.1
Coordinates 543413..543637 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS091_RS02765 539002..539172 + 171 WP_000713595.1 hypothetical protein -
OS091_RS02770 539186..539804 + 619 Protein_476 recombinase family protein -
OS091_RS02775 539804..540481 + 678 Protein_477 DNA topoisomerase -
OS091_RS02780 540963..541289 + 327 WP_000392725.1 hypothetical protein -
OS091_RS02785 541290..541706 + 417 WP_000323438.1 recombinase -
OS091_RS02790 541726..543270 + 1545 WP_002390960.1 recombinase family protein -
OS091_RS02795 543413..543637 + 225 WP_000205227.1 helix-turn-helix transcriptional regulator Antitoxin
OS091_RS02800 543652..544521 + 870 WP_000233000.1 nucleotidyltransferase domain-containing protein Toxin
OS091_RS02805 544502..545236 + 735 WP_000662263.1 class I SAM-dependent methyltransferase -
OS091_RS02810 545269..546177 + 909 WP_001255866.1 aminoglycoside nucleotidyltransferase ANT(6)-Ia -
OS091_RS02815 546174..546654 + 481 Protein_485 GNAT family N-acetyltransferase -
OS091_RS02820 546747..547541 + 795 WP_001096887.1 aminoglycoside O-phosphotransferase APH(3')-IIIa -
OS091_RS02825 548083..548166 + 84 WP_001814874.1 23S rRNA methyltransferase attenuation leader peptide -
OS091_RS02830 548291..549028 + 738 WP_001038790.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island ant(6)-Ia / aph(3')-III / erm(B) - 537999..553944 15945
- flank IS/Tn ant(6)-Ia / aph(3')-III / erm(B) - 545269..553944 8675


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polymerase, nucleotidyl transferase domain

(12-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-57)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 32926.57 Da        Isoelectric Point: 4.8781

>T265241 WP_000233000.1 NZ_CP113037:543652-544521 [Staphylococcus aureus]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI

Download         Length: 870 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8365.68 Da        Isoelectric Point: 4.5510

>AT265241 WP_000205227.1 NZ_CP113037:543413-543637 [Staphylococcus aureus]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGEEIKISNE

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R3JIN1

Antitoxin

Source ID Structure

References