265234

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2259272..2259786 Replicon chromosome
Accession NZ_CP113032
Organism Staphylococcus aureus strain Akali

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag OS080_RS11795 Protein ID WP_000581792.1
Coordinates 2259272..2259481 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag OS080_RS11800 Protein ID WP_000138932.1
Coordinates 2259493..2259786 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS080_RS11775 (2254780) 2254780..2256138 - 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
OS080_RS11780 (2256153) 2256153..2257223 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
OS080_RS11785 (2257541) 2257541..2258743 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
OS080_RS11790 (2259007) 2259007..2259144 - 138 WP_000828354.1 Lmo0850 family protein -
OS080_RS11795 (2259272) 2259272..2259481 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
OS080_RS11800 (2259493) 2259493..2259786 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
OS080_RS11805 (2259952) 2259952..2261436 + 1485 WP_000571549.1 cardiolipin synthase -
OS080_RS11810 (2261464) 2261464..2262111 + 648 WP_001187629.1 HD domain-containing protein -
OS080_RS11815 (2262924) 2262924..2263796 - 873 WP_000725802.1 membrane protein insertase YidC -
OS080_RS11820 (2263882) 2263882..2264523 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T265234 WP_000581792.1 NZ_CP113032:c2259481-2259272 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT265234 WP_000138932.1 NZ_CP113032:c2259786-2259493 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References