265233

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2239516..2240045 Replicon chromosome
Accession NZ_CP113032
Organism Staphylococcus aureus strain Akali

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag OS080_RS11705 Protein ID WP_000621175.1
Coordinates 2239516..2239878 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag OS080_RS11710 Protein ID WP_000948331.1
Coordinates 2239875..2240045 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS080_RS11685 (2236495) 2236495..2237265 - 771 WP_001041103.1 RNA polymerase sigma factor SigB -
OS080_RS11690 (2237240) 2237240..2237719 - 480 WP_001190829.1 anti-sigma B factor RsbW -
OS080_RS11695 (2237721) 2237721..2238047 - 327 WP_001052491.1 anti-sigma factor antagonist -
OS080_RS11700 (2238166) 2238166..2239167 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
OS080_RS11705 (2239516) 2239516..2239878 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OS080_RS11710 (2239875) 2239875..2240045 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
OS080_RS11715 (2240130) 2240130..2241278 - 1149 WP_001281145.1 alanine racemase -
OS080_RS11720 (2241344) 2241344..2241703 - 360 WP_000581200.1 holo-ACP synthase -
OS080_RS11725 (2241707) 2241707..2242198 - 492 WP_001205910.1 PH domain-containing protein -
OS080_RS11730 (2242185) 2242185..2243768 - 1584 WP_001294626.1 PH domain-containing protein -
OS080_RS11735 (2243761) 2243761..2244240 - 480 WP_001287088.1 hypothetical protein -
OS080_RS11740 (2244448) 2244448..2245008 - 561 WP_001092411.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T265233 WP_000621175.1 NZ_CP113032:c2239878-2239516 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT265233 WP_000948331.1 NZ_CP113032:c2240045-2239875 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References