265228

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1967111..1967887 Replicon chromosome
Accession NZ_CP113032
Organism Staphylococcus aureus strain Akali

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag OS080_RS09895 Protein ID WP_000031108.1
Coordinates 1967111..1967263 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag OS080_RS09900 Protein ID WP_001251224.1
Coordinates 1967288..1967887 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS080_RS09880 (1963074) 1963074..1963895 + 822 WP_000669375.1 RluA family pseudouridine synthase -
OS080_RS09885 (1964358) 1964358..1965743 - 1386 WP_000116224.1 class II fumarate hydratase -
OS080_RS09890 (1965939) 1965939..1966334 - 396 WP_000901021.1 hypothetical protein -
OS080_RS09895 (1967111) 1967111..1967263 - 153 WP_000031108.1 SAS053 family protein Toxin
OS080_RS09900 (1967288) 1967288..1967887 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
OS080_RS09905 (1968046) 1968046..1968516 - 471 WP_000181398.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
OS080_RS09910 (1968521) 1968521..1969648 - 1128 WP_000379978.1 tRNA epoxyqueuosine(34) reductase QueG -
OS080_RS09915 (1969799) 1969799..1970521 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
OS080_RS09920 (1970514) 1970514..1971971 - 1458 WP_000649907.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T265228 WP_000031108.1 NZ_CP113032:c1967263-1967111 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT265228 WP_001251224.1 NZ_CP113032:c1967887-1967288 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References