Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1402462..1403238 Replicon chromosome
Accession NZ_CP113029
Organism Staphylococcus aureus strain Zoe

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag OS075_RS07340 Protein ID WP_000031108.1
Coordinates 1403086..1403238 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag OS075_RS07335 Protein ID WP_001251224.1
Coordinates 1402462..1403061 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS075_RS07315 (1398378) 1398378..1399835 + 1458 WP_000649907.1 ABC transporter permease subunit -
OS075_RS07320 (1399828) 1399828..1400550 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
OS075_RS07325 (1400701) 1400701..1401828 + 1128 WP_000379978.1 tRNA epoxyqueuosine(34) reductase QueG -
OS075_RS07330 (1401833) 1401833..1402303 + 471 WP_000181398.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
OS075_RS07335 (1402462) 1402462..1403061 + 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
OS075_RS07340 (1403086) 1403086..1403238 + 153 WP_000031108.1 SAS053 family protein Toxin
OS075_RS07345 (1404015) 1404015..1404410 + 396 WP_000901021.1 hypothetical protein -
OS075_RS07350 (1404606) 1404606..1405991 + 1386 WP_000116224.1 class II fumarate hydratase -
OS075_RS07355 (1406454) 1406454..1407275 - 822 WP_000669376.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T265220 WP_000031108.1 NZ_CP113029:1403086-1403238 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT265220 WP_001251224.1 NZ_CP113029:1402462-1403061 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References