Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1202012..1202541 Replicon chromosome
Accession NZ_CP113029
Organism Staphylococcus aureus strain Zoe

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag OS075_RS06075 Protein ID WP_000621175.1
Coordinates 1202179..1202541 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag OS075_RS06070 Protein ID WP_000948331.1
Coordinates 1202012..1202182 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS075_RS06040 (1197049) 1197049..1197609 + 561 WP_001092411.1 K(+)-transporting ATPase subunit C -
OS075_RS06045 (1197817) 1197817..1198296 + 480 WP_001287088.1 hypothetical protein -
OS075_RS06050 (1198289) 1198289..1199872 + 1584 WP_001294626.1 PH domain-containing protein -
OS075_RS06055 (1199859) 1199859..1200350 + 492 WP_001205910.1 PH domain-containing protein -
OS075_RS06060 (1200354) 1200354..1200713 + 360 WP_000581200.1 holo-ACP synthase -
OS075_RS06065 (1200779) 1200779..1201927 + 1149 WP_001281145.1 alanine racemase -
OS075_RS06070 (1202012) 1202012..1202182 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
OS075_RS06075 (1202179) 1202179..1202541 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OS075_RS06080 (1202891) 1202891..1203892 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
OS075_RS06085 (1204011) 1204011..1204337 + 327 WP_001052491.1 anti-sigma factor antagonist -
OS075_RS06090 (1204339) 1204339..1204818 + 480 WP_001190829.1 anti-sigma B factor RsbW -
OS075_RS06095 (1204793) 1204793..1205563 + 771 WP_001041103.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T265216 WP_000621175.1 NZ_CP113029:1202179-1202541 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT265216 WP_000948331.1 NZ_CP113029:1202012-1202182 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References