Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1182271..1182785 Replicon chromosome
Accession NZ_CP113029
Organism Staphylococcus aureus strain Zoe

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag OS075_RS05985 Protein ID WP_000581792.1
Coordinates 1182576..1182785 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag OS075_RS05980 Protein ID WP_000138932.1
Coordinates 1182271..1182564 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS075_RS05960 (1177534) 1177534..1178175 + 642 WP_000483153.1 thiamine phosphate synthase -
OS075_RS05965 (1178261) 1178261..1179133 + 873 WP_000725802.1 membrane protein insertase YidC -
OS075_RS05970 (1179946) 1179946..1180593 - 648 WP_001187629.1 HD domain-containing protein -
OS075_RS05975 (1180621) 1180621..1182105 - 1485 WP_000571549.1 cardiolipin synthase -
OS075_RS05980 (1182271) 1182271..1182564 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
OS075_RS05985 (1182576) 1182576..1182785 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
OS075_RS05990 (1182913) 1182913..1183050 + 138 WP_000828354.1 Lmo0850 family protein -
OS075_RS05995 (1183314) 1183314..1184516 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
OS075_RS06000 (1184834) 1184834..1185904 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
OS075_RS06005 (1185919) 1185919..1187277 + 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T265215 WP_000581792.1 NZ_CP113029:1182576-1182785 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT265215 WP_000138932.1 NZ_CP113029:1182271-1182564 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References