Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1445018..1445794 Replicon chromosome
Accession NZ_CP113027
Organism Staphylococcus aureus strain Syndra

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag OS083_RS07585 Protein ID WP_000031108.1
Coordinates 1445642..1445794 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A6B1RP77
Locus tag OS083_RS07580 Protein ID WP_001251218.1
Coordinates 1445018..1445617 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS083_RS07560 (1440934) 1440934..1442391 + 1458 WP_000649908.1 ABC transporter permease subunit -
OS083_RS07565 (1442384) 1442384..1443106 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
OS083_RS07570 (1443257) 1443257..1444384 + 1128 WP_000379977.1 tRNA epoxyqueuosine(34) reductase QueG -
OS083_RS07575 (1444389) 1444389..1444859 + 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
OS083_RS07580 (1445018) 1445018..1445617 + 600 WP_001251218.1 glucosamine-6-phosphate isomerase Antitoxin
OS083_RS07585 (1445642) 1445642..1445794 + 153 WP_000031108.1 SAS053 family protein Toxin
OS083_RS07590 (1446457) 1446457..1446852 + 396 WP_000901022.1 hypothetical protein -
OS083_RS07595 (1447048) 1447048..1448433 + 1386 WP_000116233.1 class II fumarate hydratase -
OS083_RS07600 (1448898) 1448898..1449719 - 822 WP_000669384.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T265201 WP_000031108.1 NZ_CP113027:1445642-1445794 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT265201 WP_001251218.1 NZ_CP113027:1445018-1445617 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFIVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A6B1RP77

References