Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1293060..1293589 Replicon chromosome
Accession NZ_CP113027
Organism Staphylococcus aureus strain Syndra

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag OS083_RS06710 Protein ID WP_000621175.1
Coordinates 1293227..1293589 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag OS083_RS06705 Protein ID WP_000948331.1
Coordinates 1293060..1293230 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS083_RS06675 (1288096) 1288096..1288656 + 561 WP_001092405.1 K(+)-transporting ATPase subunit C -
OS083_RS06680 (1288865) 1288865..1289344 + 480 WP_001287083.1 hypothetical protein -
OS083_RS06685 (1289337) 1289337..1290920 + 1584 WP_001294642.1 PH domain-containing protein -
OS083_RS06690 (1290907) 1290907..1291398 + 492 WP_001205915.1 PH domain-containing protein -
OS083_RS06695 (1291402) 1291402..1291761 + 360 WP_000581194.1 holo-ACP synthase -
OS083_RS06700 (1291827) 1291827..1292975 + 1149 WP_001280702.1 alanine racemase -
OS083_RS06705 (1293060) 1293060..1293230 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
OS083_RS06710 (1293227) 1293227..1293589 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OS083_RS06715 (1293938) 1293938..1294939 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
OS083_RS06720 (1295058) 1295058..1295384 + 327 WP_001052491.1 anti-sigma factor antagonist -
OS083_RS06725 (1295386) 1295386..1295865 + 480 WP_001190825.1 anti-sigma B factor RsbW -
OS083_RS06730 (1295840) 1295840..1296610 + 771 WP_001041107.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T265200 WP_000621175.1 NZ_CP113027:1293227-1293589 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT265200 WP_000948331.1 NZ_CP113027:1293060-1293230 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References