Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1273335..1273849 Replicon chromosome
Accession NZ_CP113027
Organism Staphylococcus aureus strain Syndra

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag OS083_RS06620 Protein ID WP_000581792.1
Coordinates 1273640..1273849 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag OS083_RS06615 Protein ID WP_000138934.1
Coordinates 1273335..1273628 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS083_RS06595 (1268596) 1268596..1269237 + 642 WP_000483147.1 thiamine phosphate synthase -
OS083_RS06600 (1269323) 1269323..1270195 + 873 WP_000725802.1 membrane protein insertase YidC -
OS083_RS06605 (1271010) 1271010..1271657 - 648 WP_001187610.1 HD domain-containing protein -
OS083_RS06610 (1271685) 1271685..1273169 - 1485 WP_000571549.1 cardiolipin synthase -
OS083_RS06615 (1273335) 1273335..1273628 + 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
OS083_RS06620 (1273640) 1273640..1273849 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
OS083_RS06625 (1273977) 1273977..1274114 + 138 WP_000828354.1 Lmo0850 family protein -
OS083_RS06630 (1274378) 1274378..1275580 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
OS083_RS06635 (1275898) 1275898..1276968 + 1071 WP_000159641.1 D-alanine--D-alanine ligase -
OS083_RS06640 (1276983) 1276983..1278341 + 1359 WP_000611468.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T265199 WP_000581792.1 NZ_CP113027:1273640-1273849 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT265199 WP_000138934.1 NZ_CP113027:1273335-1273628 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References